Respiratory Diseases

Immustim Solution

Immustim Solution 3d

Indications

Immunostimulator against viral and bacterial  infections of respiratory and  urinary tracts ; also relieves  nasopharyngeal  catarrh  and tonsillitis .

Dosage

Take 3 tablets a day with  some water, 2.5cc of Solution three times a day.

Contraindication

Internal or external use should not exceed a period of 8 successive weeks .
 Occasionally allergic reactions may occur owing to allergy to plants .

  Pregnancy and Lactation : There are no reliable study on this subject . Therefore , administration   of  the drug during  pregnancy and /or  lactation  is not    recommended .

 

 Side effects: Occasionally allergic reactions may occur owing to allergy to plants.

 Contraindications: Allergy to the plant . Echiherb should not be used in serious conditions  such as Tuberculosis, Multiple Sclerosis , AIDS , HIV  infection , and autoimmune disorders.

 Precautions: Internal or external  use should not exceed  a period of 8 successive weeks .

 Internal or external use should not exceed a period of 8 successive weeks .
 Occasionally allergic reactions may occur owing to allergy to plants .

  Pregnancy and Lactation : There are no reliable study on this subject . Therefore , administration   of  the drug during  pregnancy and /or  lactation  is not    recommended .

 

 Side effects: Occasionally allergic reactions may occur owing to allergy to plants.

 Contraindications: Allergy to the plant . Echiherb should not be used in serious conditions  such as Tuberculosis, Multiple Sclerosis , AIDS , HIV  infection , and autoimmune disorders.

 Precautions: Internal or external  use should not exceed  a period of 8 successive weeks .

 

Composition

Each tablet contains dried juice of  aerial  parts of Echinacea purpureae  114 mg , each 100mg of oral solution contains 80 mg dried juice of aerial parts of Echinacea purpureae.

Drug Form

Oral solution

Stands On

  Stands on:

  Tablet 0.41 – 0.5mg Flavonoid according to quercetin. 

  Solution : 1.27 – 1.72mg/ml phenolic compounds on the basis of chlorogenic Acid .

Pharmacological actions

Current claims of the effectiveness of  Echinacea  purpurea as a stimulator of the immune system  are  based on  numerous scientific studies. The immunostimulant effect is brought about by three mechanisms: activation of phagocytosis and stimulation of fibroblasts; increasing respiratory activity; and improving  mobility of the leukocytes . Phagocytic activity of standardized extracts of the aerial  parts of E.purpurea has been  determined (1,4,5,6) . A lyophylisate of the expressed juice of E.purpurea significantly increased the  percentage of phagocytizing human granulocytes  and  stimulated the phagocytosis of yeast particles in  vitro. The pharmacological activity of  Echinacea has been attributed to five component fractions in addition to the essential  oil namely the alkyl amides , caffeic  acid derivatives , polyalkenes , and  polysaccharides (5) . The  lipophilic amides , alkamids , and  caffeic acid  derivatives appear to contribute to the immunostimulant activity of   the alcoholic Echinacea  extracts by stimulating phagoctosis of polymorphonuclear neutrophil granulocytes (1) . High  molecular weight polysaccharides, including  heteroxylan, which activates phagocytosis, and  arabinogalactan, which promotes, the release of tumour necrosis factor and the productions of interleukin 1 and interferon beta (3,4) , have also been implicated in the activity of the aqueous extracts and the powdered drug when taken orally .Recently, 26 controlled clinical trials (18 randomized, 11 double – blind) were systemically reviewed in Germany (2). Nineteen trials studied the prophylaxis or curative treatment of infections, four trials studied the reduction of side effects of chemotherapy , and three investigated the modulation of specific  immune parameters . The reviewconcluded that Echinacea – containing preparations are efficacious immunomodulators .

Reference

1. Stotzem CD . Hungerland U . Mengs U . Influence of Echinacea purpurea on the phagocytosis of human granulocytes . Medical cience research ,1992  , 20 ; 719 –720 .

2. Bithner E . Die  Wirkung von Echinacin auf die Funktion des Retikuloendothelialen systems [Dissertation]. Frieburg ,University of Freiburg , 1969.

3. A Wang  DVC Kindack DG . Herbal medicine Echinacea . Canadian Pharmaceutical journal ,  1991 , 124 : 512 – 516.

4. Bauer R, Wagner  H . Echinacea species as potential immunostimulatory drugs. In : Wegner H, Farnswort NR , eds .Economic and medicinal plants research.

Vol –5 . London ,Academic Press , 1991 : 253 – 321 .

5. Bruneton J. Pharmacognosy , phytochemistry , medicinal plants Paris ,   Lavoisier , 1995.

6.Bauer R et at Immunological  in vivo examinations of Echinacea extracts . Arzneimittelforschung ,1988 . 38 : 276 – 281 .