Respiratory Diseases

Diatussin Syrup

Diatusin 3d

Indications

Antitussive, Expectorant, suitable for diabetic patients

Dosage

Children's : one teaspoon to be taken three times a day .

Adult and Children over six years old : Two teaspoons three times a day. This product is suitable for diabetic patients .

Contraindication

Side Effects : There has been no report of side effects so far .

Contraindications : Because of the presence of Asparatame in phenyl Ketonurea should be avoided . Because of sorbitol, in patients with genetic tolerance to fructose or kidney, liver failure, it is contraindicated .

Pregnancy and Lactation : It can be used under supervision of a physician.

Composition

Each 5 ml contains: Fluid extract of thymus vulgaris 750mg

Constituents

Phenols including thymol and carvacrol , cineol , borneol, geranial linalool, bornyl and linalyl acetate .

Drug Form

Syrup

Stands On

Standardized on :The basis of 30-35 mg thymol /100 ml syrup

Pharmacological actions

Antitussive, expectorant and antispasmodic actions are considered to be the major pharmacological properties of thyme(1) and have been associated with the volatile oils(e.g. thymol . carvacrol) and flavonoid constituents (2).The volatile oil in the herb most likely tissues in humans(3). The herb and/ or its extract is approved by commission E for the treatment of bronchitis, whooping cough and upper respiratory inflammation. In a double – blind, randomized study, 60patients with productive cough received either syrup of thyme or bromhexine for a period of 5 days. There was no significant difference between the two groups based on self – reported symptom relief. Both groups made similar gains (4). Extracts of thyme demonstrate anti-inflammatory effects on guinea pig tracheal smooth muscle tissue in vitro (5). The antibacterial and antifungal activity of thymol is well recognized. Thymol, carvacrol, cinnamaldehyde and eugenol showed inhibitory activities in seven oral bacteria (6). A broad spectrum of activity was observed for thymol and carvacrol against bacteria involved in upper respiratory tract infections(7).

Reference

1. Van den Broucke Co. 1983. The therapeutic value of thymus species. Fitoterapia ; 4:171-4.

2. Nawal, C.A., Guide for health – care professionals; London: The pharmaceutical press .

3. Tyler, V.E. 1994, Herbs of choice; The therapeutic use of phytomedicinals. New York, pharmaceutical products press. .

4. Leung, A.Y. and S. Foster 1996 . Encyclopedia of common natural ingredients used in Food, Drugs and Cosmetics, 2 nd ed. New York. John wiley, Sons . Inc .

5. Knols G. stal Pc, Van Ree J.W.Huisart Wetens 1994; 37(9): 392 .

6. Shapiro S, Guggenheim B. Oral microbial. Immunol. 1994, 10(4): 241 – 246 . .

7. Martindale; The complete drug reference. 34, ed . (2005), p.1755 .