As a sedative in the treatment of insomnia , anxiety and nervous tension. Alleviates
irregularity of heart beats due to stressful situations.
Neurogol : Take one to two coated tablets two times a
day with some water .
For anxiety Disorder :
- Adults and adolescents one tablet, 2 times a day .
- in children 6 years old and over, one tablet a day .
Warning: Avoid driving and working with instrumentation 2 hours after use .
Pregnancy and Lactation : The safety of valerian during pregnancy and lactation has not yet been established and should therefore , be avoided . Packaging: Coated tablets are available in boxes of 30
Each coated tablet contains : Dried extract of Valeriana officinalis 160 mg Dried extract of Melissa officinalis 80 mg Each Neurogol fort coated tablet contains: Dried extract of Valeriana officinalis 320mg Dried extract of Melissa officinalis 160mg
Alkaloids: Valerine, valerianine,
isovaltrate and valtrate .Volatile oils and - pinene, camphene, borneol, eugenol, caryophyllene , valerenol , valerianol , and valerenic acid citral a,b,
geraniol , flavonoids , rhamnosine , caryophyllene
oxide and linalool.
Coated tablet Neurogol
Valerian has demonstrated a number of pharmacological effects including (1,2) : Normalizing of the central nervous system ( it acts as a sedative in states of agitation and a stimulant in cases of extreme fatigue). A recent pharmacological study indicated that both valepotriates and valerenic acid are capable of binding to GABA receptors in a similar fashion to benzodiazepines (3). However, valerian does not appear to act in a similar way, in that, side – effects such as impaired mental function morning hangover, and dependency have not been reported with valerian . In addition , valerian compounds which do not bind to GABA receptors have also been shown to produce sedative effects. Several recent clinical studies have substantiated valerian's ability to improve sleep quality and reduce night – time awakenings in sufferers of insomnia (4). This study , performed under strict laboratory conditions , demonstrated that valerian is as effective in reducing sleep latency as small doses of barbiturates or benzodiazepines. However while these latter compounds also increase morning sleepiness, valerian usually reduces morning sleepiness. In another study of insomnias, subjects received either a valerian preparation and /or placebo (5). Compared with the placebo , valerian showed a significant effect, with 44% reporting perfect sleep and 89% reporting improved sleep. And finally , in another double – blind study of insomniacs , 20 subjects received a combination of valerian root (160 mg ) and Melissa officinalis (80 mg), a benzodiazepine (triazolam 0.125)
, or placebo (6). In the insomniac group , the valerian preparation showed an effect comparable to that of the benzodiazepine, as well as an increase in deep sleep
stage 3 and 4. The valerian preparation did not ,
however , cause day time sedation and there was no evidence of diminished concentration based on the concentration performance test or any impairment of physical performance.
1. Hendricks H et .al . Pharmacological screening of valerenal and some other components of essential oil of valeriana officinalis planta Med. 1981 ; 42:62- 8 .
2. Wegner H et al . Comparative studies on the sedative action of valeriana extracts, valepotriates and their degradation products . Planta Med 1980 ; 39 : 358 – 365 .
3. Mennini T , et al . In vitro study on the interaction of extracts and pure compounds from Valeriana
officinalis roots with .GABA , benzodiazepine and barbiturate receptors in rat brain .Fitoterapia 1993;
54: 291 – 300.
4. Leath wood PD ,chauffard F . Aqueous extract of valerian reduces latenay to fall asleep in man .Planta Medica 1985 , 54 : 144- 148 .
5. Lindahl O , Lindwall L . Double blind study of valerian preparation .Pharmacol Biochem Behau 1989 ; 32 : 1065 – 1066 .
6. Dressing H , Riemann D , Low H .Insomnia . Are Valerian / Melissa combinations of equal value to benzodiazepine. Therapiewoche 1992; 42:726 –736 .