Neurology and Psychiatry

Memoral Capsule

MemoralE 3d

Indications

Brain vascular insufficiency (e.g memory loss, cognitive decline, Alzheimer, to treat MS).

Dosage

Take one or two capsule 3 times a day with some water.

Contraindication

Side effects : Rare cases of headache , mild gastrointestinal side effects.

Pregnancy and Lactation:Duringpregnancyand lactationmaybeusedunderaphysician'ssupervision only.

Composition

Each capsule contains 360 mg gum resin of Boswellia serrata and 36 mg Zingiber rhizome powder. Based on 8.4-10.4 mg total essence and 140-172 mg gum and mucilage.

Constituents

The most important constituent of Boswellia is gum resin 60%, mucilage 20-23%, and essence 5-9%. which contains α-β-Thujone, p-cymen, and linalool(1). B. Serrata has Boswellic acid and acetyl-11- Keto-beta boswellic acid too, which are responsible for many therapeutic effects. Zingiber contains gentialutine, gentianine, bisabolene and zingiberene.

Drug Form

Capsule

Pharmacological actions

The volatile oils in Boswellia dilate the vasculature of the brain thus can increase cerebral blood flow and can
induce a better nourishment.(2)
Boswellia extract has been demonstrated by a battery of rigorous tests to have anti-inflammatory effect, unlike non-steroidal anti-inflammatory drugs, Boswellia extract proved to have zero ulcerogenic activity(3). Boswellia extract, or specifically boswellic acid, a pentacyclic triterpenoid and its acetylated derivatives have effects on both the production of antibodies and cell mediated immunity. Boswellic acid is a potent inhibitor of lipo- oxygenase. This reduces leucotriene production, Specially LTB-4 an active chemotactic factor. Two placebo- controlled studies, involving a total of 81 individuals with rheumatoid arthritis, reported significant reduction in swelling and pain over the course of 3 months(3). Erosive synovitis is critically reliant on the generation of leukotriens LT-B4(4). An extract of Boswellia resin showed sedative and analgesic properties in rats. 3-o- Acetyl-11-Keto-β-Boswellic Acid, inhibited the synthesis of DNA,RNA and protein in human leukaemia HL-60 cells(5).

Antiasthmatic activity: In a double blind, placebo- controlled study, 40 patients of both sexes were treated with a preparation of gum resin (300 mg 3
times a day) for 6 weeks. Seventy percent of patients
showed some improvements. More recently the postulate was examined that cognitive decline in aged brain is due to inflammatory CNS changes. Aging rats with significant cognitive defects in comparison to younger ones were examined by observing vascular leakage into retina. Cognitive decline paralleled the leukotrienes mediated retinal damage.The mechanism by which Boswellia can improve memory and decline forgetfulness and treat Alzheimer is thus through its anti-inflammatory effect on the brain. B.serrata has been shown to posses other therapeutic benefits as well, may be equally successful in treating ulcerative colitis as standard therapy. B.serrata may play a role in the development of new anticancer drugs because it inhibits DNA, RNA and protein synthesis in human leukemia cells in vitro. Also in rats B.serrata gum resin decreases cholesterol and triglyceride levels. Ginger root has been shown to demonstrate anti-inflammatory effects in patients suffering from rheumatoid arthritis. The active principles of gingerol was shown to be potent inhibitors of prostaglandin synthesis. Confirming the mechanism of anti-inflammatory effects. The combination of B.serrata and Ginger show a very strong anti-inflammatory effect.

Reference

1.PDR for Herbal Medicines: Newyork (1996), P.P 969-70.
2.Ammon, H. P. T., Mack T. Singh: Inhibition of leukotriene extract of Gumresin Boswellia serrata. Planta Medica, (1991), 57, PP. 203-205.
3.Martinete, D.: Der Indische Weihrauch. Neue Aspekete eines altes Harzes. Zeitschrift fur Phytotherapie. 13, Stuttgart, (1992), PP 121-125.
4.Ammon, H. P. T: Entzundliche Darmerkarankungen. Weihrauch bei Colitis ulcerosa. DAZ, 37(3), (1997), PP. 139-40.
5.Wasielewski, S.; Maligne, G.: Weihrauchextract bei bosartigen Hirntumoren. DAZ, 137(26), (1997), PP.
2250-2251.
6.Muller–Bohn, T.: Chemie und Pharmakologie des Weihrauches; Boswelliasauren gegen Choronische Polyarthritis und Colitis Ulcerosa. DAZ, 136(48), (1996), PP. 4324, 4325.