Neurology and Psychiatry

Antimigren Drop

Antimigren 3d

Indications

Migraine headache, tension headache .

Dosage

Adults : 30 – 40 drops in a glass of cold water to be taken at the primary symptoms of migraine attack or twice a day as a preventive measure .

Contraindication

Side effects :
It may cause drowsiness.

Pregnancy and lactation :
No side effects is reported so far .

Composition

Hydroalcoholic extracts of ( 1/3 ratio ):Valeriana officinalis roots 30% , Foeniculum vulgare fruits 30% ,Salix alba barks 20% , Melissa officinalis leaves 20%.

Constituents

Foeniculum vulgare : anethole , fenchone , methyl chavicol , estragole flavonoids , stilbene , beta– sisterol , limonene , coumarins (bergapten and sterols , myrcene ).Valeriana

officinalis :
valerianine , isovaltrate , valerenic acid , valepotriates, pinene , camphene, borneol , eugenol .
chlorogenic acid , valtrate , valerenol , flavonoids .Mellisa officinalis : Citral , citronellal , geraniol , eugenol , caryophyllene , flavonoids , luteoline – 7- glucoside , ramnasine , cosmosin , rhamnocitrin .

Salix alba :
various phenolic glycosides including salicin , salicortin , salireposide , picein ,and triandrin , catechins , salicortin .

Stands On

Stands on
71- 78  Anethole in 100 ml . and 0.27% - 0.33% Flavenol – o – Ghycosides in dry extract ( Based on Quercetin ) .

Pharmacological actions

Migraine , migraine - like headaches , and neuralgia are a common problem today . Considerable evidence supports an association between migraine headache and vasomotor instability ,but the mechanisms are not yet known (1).

The mechanism of migraine can be described as a three- stage process :

initiation , prodrome , and headache . Although , a particular stressor may be associated with the onset of a specific attack , it appears that initiation is dependent on accumulation over time of several stressors . These stressors ultimately affect serotonin metabolism (2).

Once a critical point of susceptibility is reached , a cascade event is initiated :

.decreased tissue serotonine levels. Changes in the platelet , alteration in responsiveness of key cerebrovascular end – organs and the build up of histamine , arachidonic acid metabolites , or other mediators of inflammation (3).

Antimigraine herbal drop is a combination of several plant extracts and is able to relieve the patients from the severe headache . In a clinical trial in two groups of 35 patients with migraine headache , one group was treated with antimigraine drop for 12 weeks and another group with propranolol for the same period of time . The results showed that both drugs were equally effective in reducing the intensity , frequency and the duration of headache , however , the patients were more satisfied with antimigraine compare to propranrolol (4,5) .

The mechanism of action of antimigraine is :

Valepotriates and valerenic acid binds to GABA receptors in a similar fashion to benzodiazepines (6,7) ,

and induce sedation . The sedative action of the constituents of Valeriana officinalis overall , can inhibit the stressors by which migraine headache is initiated . Also , salicin and other phenol glycosides from Salix alba inhibit the synthesis of prostaglandins and has a potent anti-inflammatory and analgesic effect therefore ,it can relieve the patient headache effectively .

Reference

1.Shinhoj E.: Arch . Neurol 1979 ; 257 – 266 .
2.Rose F.C– TINS 1983: 6:247 .
3.Hanington E. Headache 1986;26: 411– 415 .
4.Moattar F.and Kafil M.:Abstract of 9 th. Iranian Congress of Physiology and Pharmacology .Tehran 1988 .
5. Chitsaz .A: unpublished data 2000.
6.Mennini T . et al .: Fitoterapia 1993.54: 291 – 300 .
7.Wagner H .et al. Planta Med . 1980; 358- 365 .