Kidney and Urinary Tract Diseases

Prostatan Tablet

Indications

Effective in Benign Prostatic Hyperplasia,  prostate –  related   urinary discomfort , increases urine  flow

Dosage

One to two tablets three times a day after meal is taken with some water.

Contraindication

Contraindications and cautions  :  Prostatan tablet is not recommended for children.

Composition

Each  coated  tablet of  Prostatan  contains the hydroalcoholic  dry extracts of the following: Urtica dioica  28 mg , Cucurbita pepo  

25 mg ,Tribulus terrestris 22 mg, Matricaria chamomilla  18 mg, Pimpinella anisum17 mg                  

Stands on: 0.52 –0.60mg Flavonoid –o – glycosides in  each  tablet .

Constituents

Urtica  dioica  L.: Flavonol  glycosides , sterols , scopoletin , vitamins , and phenolic acids. Cucurbita pepo : Cucurbitin squalene, minerals(Zn, Se, Ca, Cu, K, Fe, Mn, P, Mg) .Matricaria  chamomilla :  Apigenin , umbeliferone , apigenin , apigetrine, apiin , quercetin , bisabolol , chamazulene.

Tribulus terrestris : Steroidal saponins

( terrestrazine , diosin , gracilin , glycosides

( terboloside  ),flavonoids .

Pimpinella anisum:   Anethole, estragole, scopoletin, quercetin, bergapten.

Drug Form

Coated tablet

Stands On

Stands on: 0.52 –0.60mg Flavonoid –o – glycosides in  each  tablet .

Pharmacological actions

Benign  Prostatic  Hyperplasia ( BPH ) or hypertrophy ( BPR ) is a common condition  that affects more than half of all men by age of 50 with symptoms often appearing as early as age 40 or even younger. While the etiology of BPR has not been fully clarified , it appears to be influenced  by age related changes in sex  hormone physiology (1). Prostatic enlargement results in the accumulation  of prostatic  dihydrotestosterone(DHT ) , which is a more potent  form of testosterone(2).DHT, which has a greater affinity for the androgen receptors than  testosterone , stimulates the hyperproliferation of prostatic tissue by binding to the stromal and epithelial androgen receptors , promoting  the synthesis of nuclear mRNA and cell growth (2,3 ). Testosterone is converted  to DHT by  5 – alpha – reductase enzyme. While this conversion process is required for normal growth of prostate, an increase  in the activity of this enzyme has been shown to occur in prostate hyperplastic tissue compared to normal prostate Prostatan  tablet and/or drop inhibit the activity of this enzyme ( 5-alpha- reductase ) and this can help to decrease prostate size. The active constituents of Urtica dioica reduce binding activity  of human  sex hormone– binding globulin  to testosterone ( 3,4 ). Adding to this fact it is interesting to know hat the extract of Urtica dioica showed partial concentration – dependent inhibition  of both cyclooxygenase and 5-lipooxygenase – derived reactions, which inhibits the prostaglandin synthesis in the prostate tissue (5). Flavonoids and  polysaccharides  isolated from Urtica  dioica can reduce prostate inflammation. The recent investigations on Cucurbita pepo extract in vitro and in vivo have demonstrated that the extract is able to inhibit 5-alpha reductase in prostate tissue and show antiandrogenic and antiinflammatory effects(7,8). Commission E from Germany has recommended the cucurbita oil for the treatment of bladder disorders in hyperplasic conditions. The cucurbita oil has antioxidant substances and its anti – inflammatory effects has been demonstrated in rats. Also , the zinc content of cucurbita seeds has been shown to inhibit  alpha reductase enzyme and balances the hormonal state of  males ( 10,11).The trace mineral Zn is known to play an important role in maintaining function and health of male reproductive tissue including  prostate (12,13 ) and  it is  also helpful in  reducing urinary discomfort. Twenty eight clinical studies have shown that Zn is able to treat the urinary  discomfort in BPR patients (14,15 ). Therefore , the combination of Urtica dioica and Cucurbita pepo synergistically improve the prostate function in BPR patients and reduce the prostate size. Tribulus terrestris is a diuretic and is very helpful in the treatment of impotence which is frequently seen in BPR patients(16).Pimpinella anisum is antispasm and antiinflammation and can therefore eliminate  prostatic inflammation which is quite helpful for  BPR patients in that sense.

Reference

1.Schottner M,et al.:Nat.Prod 1998;61 (1) ; 119- 121 .

2.Ziegler H.:Fortschr.Med  1982 ;100 (39):1832 – 34 .

3.Odenthal KP . : Phytotherapy of  benign  prostatic  hyperplasia (BPH)with cucurbita , hypoxis , pygeum , urtica and  Sabal serulata .Phyto Res. 1996 ;10:5141 – 5143 .

4.Vontobel Hg et al . : Results of a double – blind  study on the effectiveness of  ERU ( extractum radicis  urticae ) capsules in conservative  treatment of benign prostatic hyperplasia. Urology 1985 : 24 : 49 – 51 .

5.Barsoms,Bettermans AA. Z: . Allg Med 1979 ; 55 (33) : 1947 – 1950 .

6.Stahl HP . : Z Allg Med 1984 ; 60 (3) ; 128- 132.

7.Bombardelli , E and P. Morazzoni 1997 . Cucurbita pepo L . Fitoterapia 68 (4) .

8.Fahim AT . et al .: Effect of pumpkin seed  oil  on the  level  of free radical  scavengers  induced during   adjuvant  –  arthritis  in  rats .Pharmacol Res ( 1995). 31(1): 37- 9 .

9.Hunt cd . et al . : Effect of  dietary zinc  depletion  on seminal  volume and zinc loss , serum testosterone concentrations , and sperm morphology in young  men . Am J . clin Nutr  1992 ; 56 : 148- 57 .

10.Leake A. et al .: Interaction  between prolactin and zinc in the human prostate gland .J. Endocrinal 1984 ; 102 :73 – 6 .

11.Leake  et al  . : The effect of zinc on the 5 – alpha reduction of testosterone by the hyperplastic human  prostate gland .J. Steroid   Biochem  1984 ; 20 : 651- 5 .

12.Fahim MS , et al . : Zinc  treatment  for reduction of hyperplasia     of  the  prostate .  Fed Proc 1976 ; 35:361 .

13.Bradley , P. R . (ed)  1992 : British  Herbal Compendium , vol 1 Bournemouth: British Herbal Medicine Association .

14.Jajaram S. et al  . : Indian Drugs 1993, 36 (10) , 498 – 500 .

15.Bradley , P.R (ed ) 1992. : Biritish  Herbal Association . 16- 16.Ammn   HPI , et al . : Deutsch . Apoth . Ztg  .1996, 136 (22).  17-   30 .