Gastrointestinal

Livergol Tablet 70 Mg

Livergol 70 3d

Indications

Hepatoprotective , Choleretic, Acute and chronic hepatitis , Hepatic cirrhosis. Fatty liver.

Dosage

One 140mg coated tablet or two70 mg coated
tablets 3 times a day.

Contraindication

Side effects : Drug monitoring studies evaluating more than 3500 patients using Silymarin up to 1995 indicate that adverse effects were seen in 1% of patients and consisted mainly of mild gastrointestinal complaints (7) .

Contraindications and cautions:
None known.

Other therapeutic effects : Abnormal liver function , exposure to chemical pollutant , alcoholic liver damage .
Pregnancy and Lactation : No adverse effects expected .

Composition

Each coated tablet contains dried extract of Sylibum marianum equivalent to 70  mg Silymarin .

Constituents

The plant contains flavono--lignans : silybin , silychristin , silydianin and 2,3 – dehydro derivatives . These flavanolignans are collectively known as Silymarin ; fixed oil , flavonoids , taxifolin , and sterols are also found in this plant .

Drug Form

Coated tablet 70 mg .

Pharmacological actions

The liver has several vital functions in the body. eg. it plays a dominant role in the metabolism, in digestion and in detoxification of waste products .
Every form of liver damage causes changes in liver cell membrane and impairs the functional capacity of the liver in this way.
Silymarin stimulates RNA polymerase activity
in the cell nucleus, thereby stimulating ribosomal protein synthesis in the liver cells via RNA synthesis(1). This, in turn, stimulates the regenerative capacity of the liver. Acting as a direct antioxidant and free radical scavenger (2). Increasing the intracellular glutathione and superoxide dismutase content (3). Inhibiting the formation of leukotrienes. Silymarin is effective in both acute and chronic viral hepatitis. In one study of acute , viral hepatitis, 29 patients treated with Silymarin showed a definite therapeutic influence on the characteristic increased serum levels of bilirubin and liver enzymes compared with a placebo group (4) . The laboratory parameters in the Silymarin group regressed more than in placebo group by the fifth day of treatment . The number of patients attaining normal liver values after 3 weeks treatment was significantly higher in the Silymarin group than in the placebo group . In a study in chronic viral hepatitis , Silymarin was shown to result in dramatic improvement. Usage at a high dose (420 mg of Silymarin ) for periods of 3-12 months resulted in a reversal of liver cell damage ( as noted by biopsy ) , an increase in serum protein, and a reduction in liver enzymes .
Common symptoms of hepatitis (eg. abdominal discomfort , decreased appetite , and fatigue) were all improved (5 ). In an uncontrolled study on 2000 patients suffering from toxic liver damage of different etiologies, serum levels of hepatic enzymes were considerably reduced ( 6) .

Reference

1.Sonnenbicher J. et al . : Proceedings of the
International Bioflavonoid Symposium 1981,477.
2.Valenzuela A et al.:Biological Research 1994; 27 ( 2) : 105 – 12 .
3.Rui Y . : Mem Inst Oswaldo Cruz . 1991 : 86 ( Supple ) 2:79 – 85 .
4.Brodanova M ., Filip J .: Prak Arzt 1976 ; 30 ( 346) 354 – 362 .
5.Kiesewetter E , Leodolter I , Thaler H .: Leber Magen Darm 1977:7(5) ; 318 – 323 .
6.Fintelmann V.: Med Klin 1973 : 68( 24) :
809- 815 .
7.A mild laxative effect is occasionally oserved with Silybum marianum preparations .