Effective in Benign Prostatic Hyperplasia, prostate – related urinary discomfort , increases urine flow
One to two tablets three times a day after meal is taken with some water
Contraindications and cautions : Prostatan tablet is not recommended for children
Each coated tablet of Prostatan contains the hydroalcoholic dry extracts of the following: Urtica dioica 28 mg , Cucurbita pepo
25 mg ,Tribulus terrestris 22 mg, Matricaria chamomilla 18 mg, Pimpinella anisum17 mg
Stands on: 0.52 –0.60mg Flavonoid –o – glycosides in each tablet .
Urtica dioica L.: Flavonol glycosides , sterols , scopoletin , vitamins , and phenolic acids. Cucurbita pepo : Cucurbitin squalene, minerals(Zn, Se, Ca, Cu, K, Fe, Mn, P, Mg) .Matricaria chamomilla : Apigenin , umbeliferone , apigenin , apigetrine, apiin , quercetin , bisabolol , chamazulene.
Tribulus terrestris : Steroidal saponins
( terrestrazine , diosin , gracilin , glycosides
( terboloside ),flavonoids .
Pimpinella anisum: Anethole, estragole, scopoletin, quercetin, bergapten.
Benign Prostatic Hyperplasia ( BPH ) or hypertrophy ( BPR ) is a common condition that affects more than half of all men by age of 50 with symptoms often appearing as early as age 40 or even younger. While the etiology of BPR has not been fully clarified , it appears to be influenced by age related changes in sex hormone physiology (1). Prostatic enlargement results in the accumulation of prostatic dihydrotestosterone(DHT ) , which is a more potent form of testosterone(2).DHT, which has a greater affinity for the androgen receptors than testosterone , stimulates the hyperproliferation of prostatic tissue by binding to the stromal and epithelial androgen receptors , promoting the synthesis of nuclear mRNA and cell growth (2,3 ). Testosterone is converted to DHT by 5 – alpha – reductase enzyme. While this conversion process is required for normal growth of prostate, an increase in the activity of this enzyme has been shown to occur in prostate hyperplastic tissue compared to normal prostate Prostatan tablet and/or drop inhibit the activity of this enzyme ( 5-alpha- reductase ) and this can help to decrease prostate size. The active constituents of Urtica dioica reduce binding activity of human sex hormone– binding globulin to testosterone ( 3,4 ). Adding to this fact it is interesting to know hat the extract of Urtica dioica showed partial concentration – dependent inhibition of both cyclooxygenase and 5-lipooxygenase – derived reactions, which inhibits the prostaglandin synthesis in the prostate tissue (5). Flavonoids and polysaccharides isolated from Urtica dioica can reduce prostate inflammation. The recent investigations on Cucurbita pepo extract in vitro and in vivo have demonstrated that the extract is able to inhibit 5-alpha reductase in prostate tissue and show antiandrogenic and antiinflammatory effects(7,8). Commission E from Germany has recommended the cucurbita oil for the treatment of bladder disorders in hyperplasic conditions. The cucurbita oil has antioxidant substances and its anti – inflammatory effects has been demonstrated in rats. Also , the zinc content of cucurbita seeds has been shown to inhibit alpha reductase enzyme and balances the hormonal state of males ( 10,11).The trace mineral Zn is known to play an important role in maintaining function and health of male reproductive tissue including prostate (12,13 ) and it is also helpful in reducing urinary discomfort. Twenty eight clinical studies have shown that Zn is able to treat the urinary discomfort in BPR patients (14,15 ). Therefore , the combination of Urtica dioica and Cucurbita pepo synergistically improve the prostate function in BPR patients and reduce the prostate size. Tribulus terrestris is a diuretic and is very helpful in the treatment of impotence which is frequently seen in BPR patients(16).Pimpinella anisum is antispasm and antiinflammation and can therefore eliminate prostatic inflammation which is quite helpful for BPR patients in that sense.
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