Constipation,and for bowel evacuation
Adult : 1-4 coated tablets per day, and the children older than 6 years of age 1-2 tablet daily.For children younger than 6 years of age , Senagol syrup is recommended
It is recommended that senna should not be given to patients with intestinal obstruction or with undiagnozed abdominal symptoms ; care should also be taken by patients with inflammatory bowel disease and prolonged use should be avoided.
Pregnancy and Lactation :
Laxatives usually , should not be taken during pregnancy and lactation.
Side effects :
Senna may cause mild abdominal discomfort such as colic or cramps . Prolonged use or overdo sage can result in diarrhea with excessive loss of potassium ; an atonic non- functioning colon may also develop.
The active ingredients in each coated tablets are: The dry extract of leave and fruits of Cassia spp. (50 mg).
- Rosa damascena Flowers 15.2 mg
-Foeniculum vulgare Seeds 3.6 mg
The active ingredients of senna leaves are ,anthraquinones primarily sennosides A and B with sennosides C and D polysaccharides including mucilage flavonoids including isorhamnetin
The cathartic action of anthraquinone -containing drugs is well recognized and they have been used as laxatives for many years.
Sennosides A and B ,and their natural metabolites sennidins A and B ,have been reported to act specifically on the large intestine with the acceleration of colonic transport the major component of their laxative effect . Sennosides A and B have also been reported to induce fluid
secretion exclusively in the colon ,following oral administration of the glycosides
1- Kobashi,K etal. Metabolism of sennosides by human intestinal bacteria. Planta Med 1980.40: 225 - 36
2- Leng - Peschlow E. Dual effect orally administered sennosides on large intestine transit and fluid absorption in the rat
J. Pharm Pharmacol. 1986: 38 : 606 – 10
3- Leng - Peschlow E. Acceleration of large intsetine transit time in rats by sennosidis A and B in mice. J. pharm pharmacol 1986; 38: 369 - 73